Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study.

Source

The Lancet: Microbe, 3(10), e735-e743.

Authors

Lo, S. W., Mellor, K., Cohen, R., Alonso, A. R., Belman, S., Kumar, N., Hawkins, P. A., Gladstone, R. A., von Gottberg, A., Veeraraghavan, B., Ravikumar, K. L., Kandasamy, R., Pollard, S. A. J., Saha, S. K., Bigogo, G., Antonio, M., Kwambana-Adams, B., Mirza, S., Shakoor, S., Nisar, I., Cornick, J. E., Lehmann, D., Ford, R. L., Sigauque, B., Turner, P., Moïsi, J., Obaro, S. K., Dagan, R., Diawara, I., Skoczyńska, A., Wang, H., Carter, P. E., Klugman, K. P., Rodgers, G., Breiman, R. F., McGee, L., Bentley, S. D., Muñoz-Almagro, C., Varon, E., Global Pneumococcal Sequencing Consortium

Department

Health Science

Year

2022

Abstract

Serotype 24F was identified in numerous countries mainly due to the clonal spread of three lineages: GPSC10 (CC230), GPSC16 (CC156), and GPSC206 (CC7701). GPSC10 was the only multidrug-resistant lineage. GPSC10 drove the increase in 24F in France and had high invasive disease potential. The international dataset of GPSC10 (n=888) revealed that this lineage expressed 16 other serotypes, with only six included in 13-valent PCV (PCV13). All serotype 24F isolates were clustered in a single clade within the GPSC10 phylogeny and long-range transmissions were detected from Europe to other continents. Spatiotemporal analysis showed GPSC10-24F took 3–5 years to spread across France and a rapid change of serotype composition from PCV13 serotype 19A to 24F during the introduction of PCV13 was observed in neighbouring country Spain.

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