SHIVERS influenza (flu) and respiratory virus research

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The ESR-led SHIVERS projects are aimed at improving the understanding of influenza and respiratory viruses and how to prevent their spread. 




About the SHIVERS-II study

The purpose of the new SHIVERS-II study is to better understand the immunity or protection people have against the flu through infection or vaccination. Findings of SHIVERS-II will help the New Zealand government make choices about what and when it is best to recommend for people to get their current flu vaccinations (shots). It will also help the government make decisions on how to reduce the impact of the spread of flu in the community. The study will also provide information that can be used to make better flu vaccines in the future.

The New Zealand Health & Disability Ethics Committee has approved SHIVERS-II (NTX11.11.102.AM25). SHIVERS-II is funded by the United States National Institute of Allergy and Infectious Diseases (Contract #HHSN272201400006C). 

Read more about the SHIVERS team's national science award.

SHIVERS-II objectives

  • To understand differences in how the immune system responds to the 2018 flu vaccine based on differences in participants’ histories of previous influenza vaccinations.
  • To understand differences in how the immune system responds to infections with the flu based on differences in participants’ histories of previous influenza vaccinations.
  • In the Household Transmission component aimed to measure how often and when the flu virus spreads among people who are in close contact.  

Study Update:

SHIVERS II 2018 came to an end with an amazing involvement and commitment from our participants. We received 2051 Post Season samples!

All of these samples as well as the earlier samples provided are now being tested by our scientists to determine people’s immune responses to flu across the season against the common flu viruses.  

 We are very excited to announce that SHIVERS II has been funded for 2019. The study activities will be similar to 2018 with the exception of no preseason blood sample required and also a Household transmission component introduced (more details to come).

Information for SHIVERS-II participants

For those participating again in the 2019 SHIVERS-II study, you can find the study documents, contact details and other information on the SHIVERS-II study contacts and documents webpage 

Meet the SHIVERS-II team

SHIVERS-II is multi-agency collaboration including general practices in Wellington, as well as Compass Health(external link), ESR, the Universities of Auckland(external link) and Otago(external link)Regional Public Health(external link), the Capital Coast District Health Board(external link), and SJCEIRS(external link). SHIVERS-II is being funded by the United States National Institutes of Health (US NIH) through the St. Jude Center of Excellence for Influenza Research and Surveillance (SJCEIRS) in Memphis.


From left to right: Dr Nayyereh Aminisani, Dr Claire Newbern, Associate Professor Nikki Turner, Professor Tony Dowell, Robert Press, Dr Terry Quirk, Dr Sue Huang


Logos of participating agencies